Drug interactions
Gliclazide + Lurasidone
Severity: Moderate
Gliclazide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and may worsen glycemic control in diabetic patients. Lurasidone has a relatively small metabolic effect compared with other agents in its class, but glucose control can still shift.
What this interaction means in plain words
Gliclazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: the antipsychotic may induce insulin resistance and impair insulin secretion, opposing the sulfonylurea.
What to do
Monitor blood glucose and HbA1c after starting lurasidone and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Gliclazide with Lurasidone?
MediHelp rates the interaction as moderate. Gliclazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can cause hyperglycemia and may worsen glycemic control in diabetic patients. Lurasidone has a relatively small metabolic effect compared with other agents in its class, but glucose control can still shift.
How serious is the interaction between Gliclazide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting lurasidone and adjust the antidiabetic regimen as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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