Drug interactions
Gliclazide + Mefenamic acid
Severity: Moderate
Gliclazide and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may enhance the glucose-lowering effect of sulfonylureas and has been associated with hypoglycemia. Both drugs are CYP2C9 substrates and are highly protein bound.
What this interaction means in plain words
Gliclazide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Possible competition for CYP2C9 metabolism and plasma protein binding displacement; not firmly established.
What to do
Monitor blood glucose when starting or stopping mefenamic acid and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Gliclazide with Mefenamic acid?
MediHelp rates the interaction as moderate. Gliclazide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may enhance the glucose-lowering effect of sulfonylureas and has been associated with hypoglycemia. Both drugs are CYP2C9 substrates and are highly protein bound.
How serious is the interaction between Gliclazide and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping mefenamic acid and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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