Drug interactions
Gliclazide + Moxifloxacin
Severity: Moderate
Gliclazide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both severe hypoglycemia and hyperglycemia, particularly in diabetic patients taking sulfonylureas. Moxifloxacin carries a lower risk than some other quinolones, but serious episodes have been reported, especially in older patients and those with renal impairment.
What this interaction means in plain words
Gliclazide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Quinolones block pancreatic ATP-sensitive potassium channels, increasing insulin release and adding to the sulfonylurea effect.
What to do
Monitor blood glucose closely during and shortly after the antibiotic course, and teach the patient to recognize both hypo- and hyperglycemia. Stop the quinolone and choose another antibiotic if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Gliclazide with Moxifloxacin?
MediHelp rates the interaction as moderate. Gliclazide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both severe hypoglycemia and hyperglycemia, particularly in diabetic patients taking sulfonylureas. Moxifloxacin carries a lower risk than some other quinolones, but serious episodes have been reported, especially in older patients and those with renal impairment.
How serious is the interaction between Gliclazide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and shortly after the antibiotic course, and teach the patient to recognize both hypo- and hyperglycemia. Stop the quinolone and choose another antibiotic if significant dysglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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