Drug interactions
Gliclazide + Nabumetone
Severity: Minor
Gliclazide and Nabumetone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the glucose-lowering effect of sulfonylureas, with occasional hypoglycemia. The clinical significance with nabumetone is likely small and the evidence is limited.
What this interaction means in plain words
Gliclazide and Nabumetone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Nabumetone belongs to Musculoskeletal.
Why it happens
Possible protein binding displacement or reduced sulfonylurea clearance; mechanism not clearly established.
What to do
Monitor blood glucose when starting nabumetone and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Gliclazide with Nabumetone?
MediHelp rates the interaction as minor. Gliclazide and Nabumetone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may potentiate the glucose-lowering effect of sulfonylureas, with occasional hypoglycemia. The clinical significance with nabumetone is likely small and the evidence is limited.
How serious is the interaction between Gliclazide and Nabumetone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting nabumetone and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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