Drug interactions
Gliclazide + Omeprazole
Severity: Minor
Gliclazide and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gliclazide is partly metabolized by CYP2C19 and CYP2C9, so omeprazole could modestly raise gliclazide exposure. The effect is generally small and clinically relevant hypoglycemia is uncommon.
What this interaction means in plain words
Gliclazide and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP2C19-mediated gliclazide metabolism by omeprazole.
What to do
No routine adjustment is needed. Advise patients to recognize hypoglycemia symptoms and check glucose if symptoms occur after starting omeprazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Gliclazide with Omeprazole?
MediHelp rates the interaction as minor. Gliclazide and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gliclazide is partly metabolized by CYP2C19 and CYP2C9, so omeprazole could modestly raise gliclazide exposure. The effect is generally small and clinically relevant hypoglycemia is uncommon.
How serious is the interaction between Gliclazide and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Advise patients to recognize hypoglycemia symptoms and check glucose if symptoms occur after starting omeprazole.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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