Drug interactions
Gliclazide + Peginterferon alfa 2b
Severity: Moderate
Gliclazide and Peginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can reduce CYP-mediated metabolism, and labeling advises caution with CYP2C9 substrates. Interferons also affect glucose homeostasis and can cause diabetes or dysglycemia. The net effect on gliclazide is unpredictable.
What this interaction means in plain words
Gliclazide and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Interferon-related modulation of hepatic CYP activity, plus direct effects on glucose regulation; the direction of the CYP effect is uncertain.
What to do
Monitor blood glucose regularly during peginterferon therapy and adjust the gliclazide dose according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Gliclazide with Peginterferon alfa 2b?
MediHelp rates the interaction as moderate. Gliclazide and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can reduce CYP-mediated metabolism, and labeling advises caution with CYP2C9 substrates. Interferons also affect glucose homeostasis and can cause diabetes or dysglycemia. The net effect on gliclazide is unpredictable.
How serious is the interaction between Gliclazide and Peginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during peginterferon therapy and adjust the gliclazide dose according to results.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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