Drug interactions
Gliclazide + Piroxicam
Severity: Moderate
Gliclazide and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may potentiate the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported. Piroxicam is highly protein bound and metabolized by CYP2C9, as is gliclazide.
What this interaction means in plain words
Gliclazide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Possible CYP2C9 competition and protein binding displacement; not firmly established.
What to do
Monitor blood glucose when starting or stopping piroxicam and reduce gliclazide if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Piroxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Gliclazide with Piroxicam?
MediHelp rates the interaction as moderate. Gliclazide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam may potentiate the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported. Piroxicam is highly protein bound and metabolized by CYP2C9, as is gliclazide.
How serious is the interaction between Gliclazide and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping piroxicam and reduce gliclazide if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
