Drug interactions
Gliclazide + Tacrolimus
Severity: Minor
Gliclazide and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established clinical interaction between gliclazide and tacrolimus. Tacrolimus itself can cause hyperglycemia and post-transplant diabetes, which affects glycemic control more than any pharmacokinetic effect.
What this interaction means in plain words
Gliclazide and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
No established mechanism; tacrolimus impairs insulin secretion and may increase insulin resistance.
What to do
Monitor blood glucose and tacrolimus trough concentrations as usual. Adjust the antidiabetic regimen based on glycemic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Gliclazide with Tacrolimus?
MediHelp rates the interaction as minor. Gliclazide and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established clinical interaction between gliclazide and tacrolimus. Tacrolimus itself can cause hyperglycemia and post-transplant diabetes, which affects glycemic control more than any pharmacokinetic effect.
How serious is the interaction between Gliclazide and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and tacrolimus trough concentrations as usual. Adjust the antidiabetic regimen based on glycemic response.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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