Drug interactions
Glimepiride + Indomethacin
Severity: Moderate
Glimepiride and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The interaction is inconsistent and typically modest.
What this interaction means in plain words
Glimepiride and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible displacement from protein binding and prostaglandin-mediated effects on insulin secretion; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping indomethacin and educate the patient on hypoglycemia symptoms. Reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Indomethacin?
MediHelp rates the interaction as moderate. Glimepiride and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The interaction is inconsistent and typically modest.
How serious is the interaction between Glimepiride and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping indomethacin and educate the patient on hypoglycemia symptoms. Reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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