Drug interactions
Glimepiride + Ketoprofen
Severity: Moderate
Glimepiride and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is variable and more likely in older patients or those with renal impairment.
What this interaction means in plain words
Glimepiride and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal prostaglandin-mediated clearance; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping ketoprofen and reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Ketoprofen?
MediHelp rates the interaction as moderate. Glimepiride and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is variable and more likely in older patients or those with renal impairment.
How serious is the interaction between Glimepiride and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ketoprofen and reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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