Drug interactions
Glimepiride + Linezolid
Severity: Moderate
Glimepiride and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with symptomatic hypoglycemia in diabetic patients on insulin or oral hypoglycemics, so the effect of glimepiride may be potentiated. The risk is greatest in patients with poor intake or renal impairment.
What this interaction means in plain words
Glimepiride and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
The mechanism is not established; MAO inhibition by linezolid may contribute to enhanced glucose lowering.
What to do
Monitor blood glucose more often during linezolid therapy and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Linezolid?
MediHelp rates the interaction as moderate. Glimepiride and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with symptomatic hypoglycemia in diabetic patients on insulin or oral hypoglycemics, so the effect of glimepiride may be potentiated. The risk is greatest in patients with poor intake or renal impairment.
How serious is the interaction between Glimepiride and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during linezolid therapy and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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