Drug interactions
Glimepiride + Mesalamine
Severity: Minor
Glimepiride and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can displace sulfonylureas from plasma proteins and may enhance glucose lowering, but this is described mainly with high-dose systemic salicylates. With mesalamine's low systemic salicylate exposure, the effect is unlikely to matter.
What this interaction means in plain words
Glimepiride and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride belongs to Endocrine; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Theoretical plasma protein binding displacement and intrinsic salicylate glucose-lowering effect.
What to do
No dose change is usually required; counsel the patient on hypoglycemia symptoms and check glucose if mesalamine is started at high dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride and Mesalamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mesalamine
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Mesalamine?
MediHelp rates the interaction as minor. Glimepiride and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates can displace sulfonylureas from plasma proteins and may enhance glucose lowering, but this is described mainly with high-dose systemic salicylates. With mesalamine's low systemic salicylate exposure, the effect is unlikely to matter.
How serious is the interaction between Glimepiride and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; counsel the patient on hypoglycemia symptoms and check glucose if mesalamine is started at high dose.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
