Drug interactions
Glimepiride + Oxaprozin
Severity: Moderate
Glimepiride and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is inconsistent and more likely with highly protein-bound NSAIDs, in the elderly, or with renal impairment.
What this interaction means in plain words
Glimepiride and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
Oxaprozin is highly protein bound and may displace sulfonylureas from albumin, and NSAID effects on renal prostaglandins may reduce sulfonylurea clearance; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping oxaprozin and teach patients to recognize hypoglycemia. Reduce the glimepiride dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Oxaprozin?
MediHelp rates the interaction as moderate. Glimepiride and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is inconsistent and more likely with highly protein-bound NSAIDs, in the elderly, or with renal impairment.
How serious is the interaction between Glimepiride and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping oxaprozin and teach patients to recognize hypoglycemia. Reduce the glimepiride dose if glucose falls.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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