Drug interactions
Glimepiride + Probenecid
Severity: Moderate
Glimepiride and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may modestly increase sulfonylurea exposure and enhance its glucose-lowering effect. Hypoglycemia is the potential consequence.
What this interaction means in plain words
Glimepiride and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Probenecid belongs to Genitourinary.
Why it happens
Probenecid may reduce renal excretion or metabolism of glimepiride; the mechanism is not fully established.
What to do
Monitor blood glucose when probenecid is started or stopped. Lower the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Probenecid?
MediHelp rates the interaction as moderate. Glimepiride and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid may modestly increase sulfonylurea exposure and enhance its glucose-lowering effect. Hypoglycemia is the potential consequence.
How serious is the interaction between Glimepiride and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when probenecid is started or stopped. Lower the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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