Drug interactions
Glimepiride + Quetiapine
Severity: Moderate
Glimepiride and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can impair glucose tolerance and cause hyperglycemia, which may reduce the effectiveness of glimepiride. Glycemic control may deteriorate and require treatment adjustment.
What this interaction means in plain words
Glimepiride and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Quetiapine-related insulin resistance and metabolic effects oppose the glucose-lowering action of the sulfonylurea.
What to do
Monitor blood glucose and HbA1c more frequently after starting or changing quetiapine. Adjust the glimepiride dose or add other antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Quetiapine?
MediHelp rates the interaction as moderate. Glimepiride and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can impair glucose tolerance and cause hyperglycemia, which may reduce the effectiveness of glimepiride. Glycemic control may deteriorate and require treatment adjustment.
How serious is the interaction between Glimepiride and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c more frequently after starting or changing quetiapine. Adjust the glimepiride dose or add other antidiabetic therapy as needed.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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