Drug interactions
Glimepiride + Sulindac
Severity: Moderate
Glimepiride and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is uncommon and varies between NSAIDs.
What this interaction means in plain words
Glimepiride and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and prostaglandin-related effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping sulindac and counsel the patient about hypoglycemia symptoms. Adjust the sulfonylurea dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride and Sulindac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Sulindac?
MediHelp rates the interaction as moderate. Glimepiride and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is uncommon and varies between NSAIDs.
How serious is the interaction between Glimepiride and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping sulindac and counsel the patient about hypoglycemia symptoms. Adjust the sulfonylurea dose if needed.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
