Drug interactions
Glimepiride + Tolfenamic acid
Severity: Moderate
Glimepiride and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the hypoglycemic effect of sulfonylureas. Evidence for tolfenamic acid is limited and largely extrapolated from the NSAID class.
What this interaction means in plain words
Glimepiride and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Possible protein binding displacement and reduced sulfonylurea clearance; not firmly established.
What to do
Monitor blood glucose when starting or stopping tolfenamic acid. Lower the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Glimepiride with Tolfenamic acid?
MediHelp rates the interaction as moderate. Glimepiride and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the hypoglycemic effect of sulfonylureas. Evidence for tolfenamic acid is limited and largely extrapolated from the NSAID class.
How serious is the interaction between Glimepiride and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping tolfenamic acid. Lower the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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