Drug interactions
Glimepiride + Tranylcypromine
Severity: Moderate
Glimepiride and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may enhance the hypoglycemic effect of sulfonylureas. Patients may experience unexpectedly low glucose, which can be masked by other MAOI effects.
What this interaction means in plain words
Glimepiride and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
Probable additive glucose lowering; exact mechanism uncertain.
What to do
Monitor blood glucose more frequently when starting or stopping tranylcypromine. Reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Tranylcypromine?
MediHelp rates the interaction as moderate. Glimepiride and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may enhance the hypoglycemic effect of sulfonylureas. Patients may experience unexpectedly low glucose, which can be masked by other MAOI effects.
How serious is the interaction between Glimepiride and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping tranylcypromine. Reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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