Drug interactions
Glimepiride + Warfarin
Severity: Moderate
Glimepiride and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are metabolized by CYP2C9, and the combination may change warfarin's effect or increase glimepiride's hypoglycemic effect. Clinically significant effects are uncommon but have been reported.
What this interaction means in plain words
Glimepiride and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Competition for CYP2C9 metabolism and plasma protein binding may alter the exposure of either drug.
What to do
Check INR when starting or stopping glimepiride and monitor blood glucose for hypoglycemia. Adjust either dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Warfarin?
MediHelp rates the interaction as moderate. Glimepiride and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are metabolized by CYP2C9, and the combination may change warfarin's effect or increase glimepiride's hypoglycemic effect. Clinically significant effects are uncommon but have been reported.
How serious is the interaction between Glimepiride and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR when starting or stopping glimepiride and monitor blood glucose for hypoglycemia. Adjust either dose as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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