Drug interactions
Glimepiride + Ziprasidone
Severity: Moderate
Glimepiride and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can worsen glucose control and may reduce the effectiveness of antidiabetic therapy, although ziprasidone has a relatively low metabolic risk. Patients may need a change in glucose-lowering treatment.
What this interaction means in plain words
Glimepiride and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related impairment of glucose regulation opposes the effect of the sulfonylurea; the mechanism is incompletely established.
What to do
Monitor blood glucose and HbA1c after starting or changing ziprasidone. Adjust the glimepiride dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Ziprasidone?
MediHelp rates the interaction as moderate. Glimepiride and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can worsen glucose control and may reduce the effectiveness of antidiabetic therapy, although ziprasidone has a relatively low metabolic risk. Patients may need a change in glucose-lowering treatment.
How serious is the interaction between Glimepiride and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing ziprasidone. Adjust the glimepiride dose as needed.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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