Drug interactions
Glimepiride-pioglitazone + Linagliptin
Severity: Moderate
Glimepiride-pioglitazone and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to glimepiride increases the risk of hypoglycemia. Pioglitazone does not meaningfully alter linagliptin exposure in a clinically relevant way.
What this interaction means in plain words
Glimepiride-pioglitazone and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose-lowering effect, with linagliptin enhancing glucose-dependent insulin secretion on top of sulfonylurea-stimulated secretion.
What to do
Consider reducing the glimepiride dose when adding linagliptin. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Glimepiride-pioglitazone with Linagliptin?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin added to glimepiride increases the risk of hypoglycemia. Pioglitazone does not meaningfully alter linagliptin exposure in a clinically relevant way.
How serious is the interaction between Glimepiride-pioglitazone and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when adding linagliptin. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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