Drug interactions
Glimepiride-pioglitazone + Omaveloxolone
Severity: Minor
Glimepiride-pioglitazone and Omaveloxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may lower systemic exposure of sensitive CYP2C8 substrates such as pioglitazone. This could reduce glycemic efficacy.
What this interaction means in plain words
Glimepiride-pioglitazone and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Omaveloxolone belongs to Central Nervous System.
Why it happens
Omaveloxolone is thought to induce CYP2C8, increasing pioglitazone metabolism.
What to do
Monitor glucose control and adjust the pioglitazone dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Omaveloxolone?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may lower systemic exposure of sensitive CYP2C8 substrates such as pioglitazone. This could reduce glycemic efficacy.
How serious is the interaction between Glimepiride-pioglitazone and Omaveloxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control and adjust the pioglitazone dose if control worsens.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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