Drug interactions
Glimepiride-pioglitazone + Risperidone
Severity: Moderate
Glimepiride-pioglitazone and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause hyperglycemia and weight gain, potentially worsening diabetes control despite glimepiride and pioglitazone. Antidiabetic therapy may need intensification.
What this interaction means in plain words
Glimepiride-pioglitazone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired insulin secretion.
What to do
Monitor glucose and HbA1c after starting risperidone and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Risperidone?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause hyperglycemia and weight gain, potentially worsening diabetes control despite glimepiride and pioglitazone. Antidiabetic therapy may need intensification.
How serious is the interaction between Glimepiride-pioglitazone and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting risperidone and adjust antidiabetic doses as needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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