Drug interactions
Glimepiride-pioglitazone + Rucaparib
Severity: Moderate
Glimepiride-pioglitazone and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9, which metabolizes glimepiride. Glimepiride levels may rise, which increases the risk of hypoglycemia.
What this interaction means in plain words
Glimepiride-pioglitazone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C9, which reduces glimepiride clearance.
What to do
Monitor blood glucose closely when rucaparib is started or stopped and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Glimepiride-pioglitazone with Rucaparib?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C9, which metabolizes glimepiride. Glimepiride levels may rise, which increases the risk of hypoglycemia.
How serious is the interaction between Glimepiride-pioglitazone and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when rucaparib is started or stopped and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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