Drug interactions
Glimepiride-pioglitazone + Sotagliflozin
Severity: Moderate
Glimepiride-pioglitazone and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin lowers blood glucose through SGLT inhibition and adds to the effect of glimepiride. The risk of hypoglycemia rises.
What this interaction means in plain words
Glimepiride-pioglitazone and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering between an SGLT inhibitor and an insulin secretagogue.
What to do
Consider lowering the glimepiride dose when sotagliflozin is started and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride-pioglitazone and Sotagliflozin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glimepiride-pioglitazone
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
- Glipizide-metformin + Sotagliflozin Moderate
Frequently asked questions
Can I take Glimepiride-pioglitazone with Sotagliflozin?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin lowers blood glucose through SGLT inhibition and adds to the effect of glimepiride. The risk of hypoglycemia rises.
How serious is the interaction between Glimepiride-pioglitazone and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glimepiride dose when sotagliflozin is started and monitor blood glucose.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
