Drug interactions
Carbamazepine + Sotagliflozin
Severity: Moderate
Carbamazepine and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce sotagliflozin exposure, which could weaken its glycemic and cardiovascular effects. Sotagliflozin is cleared mainly by glucuronidation.
What this interaction means in plain words
Carbamazepine and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Sotagliflozin belongs to Endocrine.
Why it happens
Carbamazepine induces UGT enzymes including UGT1A9, increasing sotagliflozin glucuronidation.
What to do
Monitor glycemic control and clinical response. Consider an alternative anticonvulsant if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Sotagliflozin
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
- Glipizide-metformin + Sotagliflozin Moderate
Frequently asked questions
Can I take Carbamazepine with Sotagliflozin?
MediHelp rates the interaction as moderate. Carbamazepine and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce sotagliflozin exposure, which could weaken its glycemic and cardiovascular effects. Sotagliflozin is cleared mainly by glucuronidation.
How serious is the interaction between Carbamazepine and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and clinical response. Consider an alternative anticonvulsant if efficacy is lost.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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