Drug interactions
Gliclazide + Sotagliflozin
Severity: Moderate
Gliclazide and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin used with gliclazide raises the risk of hypoglycemia because their glucose-lowering effects are additive.
What this interaction means in plain words
Gliclazide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT inhibition and sulfonylurea-stimulated insulin secretion.
What to do
Consider reducing the gliclazide dose when starting sotagliflozin, and monitor glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
- Glipizide-metformin + Sotagliflozin Moderate
Frequently asked questions
Can I take Gliclazide with Sotagliflozin?
MediHelp rates the interaction as moderate. Gliclazide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin used with gliclazide raises the risk of hypoglycemia because their glucose-lowering effects are additive.
How serious is the interaction between Gliclazide and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the gliclazide dose when starting sotagliflozin, and monitor glucose.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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