Drug interactions
Digoxin + Sotagliflozin
Severity: Moderate
Digoxin and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin increased digoxin exposure in interaction studies. This may raise the risk of digoxin toxicity, especially in patients with renal impairment.
What this interaction means in plain words
Digoxin and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Sotagliflozin belongs to Endocrine.
Why it happens
Likely modest inhibition of P-glycoprotein, though the mechanism is not firmly established.
What to do
Monitor serum digoxin and signs of toxicity after starting sotagliflozin. Reduce the digoxin dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
- Glipizide-metformin + Sotagliflozin Moderate
Frequently asked questions
Can I take Digoxin with Sotagliflozin?
MediHelp rates the interaction as moderate. Digoxin and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin increased digoxin exposure in interaction studies. This may raise the risk of digoxin toxicity, especially in patients with renal impairment.
How serious is the interaction between Digoxin and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin and signs of toxicity after starting sotagliflozin. Reduce the digoxin dose if concentrations rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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