Drug interactions
Chlorpropamide + Sotagliflozin
Severity: Moderate
Chlorpropamide and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding sotagliflozin to a sulfonylurea increases the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
What this interaction means in plain words
Chlorpropamide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose-lowering effects: insulin secretion stimulated by the sulfonylurea plus SGLT inhibition-driven glucosuria.
What to do
Consider reducing the chlorpropamide dose when starting sotagliflozin. Monitor blood glucose and counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
- Glipizide-metformin + Sotagliflozin Moderate
Frequently asked questions
Can I take Chlorpropamide with Sotagliflozin?
MediHelp rates the interaction as moderate. Chlorpropamide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding sotagliflozin to a sulfonylurea increases the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
How serious is the interaction between Chlorpropamide and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when starting sotagliflozin. Monitor blood glucose and counsel the patient on hypoglycemia symptoms.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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