Drug interactions
Glimepiride-pioglitazone + Trazodone
Severity: Minor
Glimepiride-pioglitazone and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has been reported to alter glucose levels in some patients, and may enhance the glucose-lowering effect of sulfonylureas such as glimepiride. The effect is inconsistent and generally small.
What this interaction means in plain words
Glimepiride-pioglitazone and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose; mechanism is not well established.
What to do
Monitor blood glucose when trazodone is started or stopped, and counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Trazodone?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has been reported to alter glucose levels in some patients, and may enhance the glucose-lowering effect of sulfonylureas such as glimepiride. The effect is inconsistent and generally small.
How serious is the interaction between Glimepiride-pioglitazone and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trazodone is started or stopped, and counsel the patient on hypoglycemia symptoms.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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