Drug interactions
Glimepiride-pioglitazone + Trimipramine
Severity: Minor
Glimepiride-pioglitazone and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter glucose homeostasis and have been associated with hypoglycemia in patients taking antidiabetic drugs. Trimipramine may therefore enhance the effect of glimepiride and pioglitazone, although the evidence is limited.
What this interaction means in plain words
Glimepiride-pioglitazone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic glucose lowering; mechanism is not firmly established.
What to do
Monitor blood glucose after starting or changing trimipramine and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride-pioglitazone and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride-pioglitazone
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Trimipramine?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can alter glucose homeostasis and have been associated with hypoglycemia in patients taking antidiabetic drugs. Trimipramine may therefore enhance the effect of glimepiride and pioglitazone, although the evidence is limited.
How serious is the interaction between Glimepiride-pioglitazone and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing trimipramine and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
