Drug interactions
Glimepiride-pioglitazone + Vadadustat
Severity: Minor
Glimepiride-pioglitazone and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of OAT1/OAT3 transporters, and drugs inhibiting these may raise its exposure, which could cause an excessive hemoglobin rise. Pioglitazone is not an established clinically relevant inhibitor.
What this interaction means in plain words
Glimepiride-pioglitazone and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3 transport reducing vadadustat renal clearance; not firmly established for pioglitazone.
What to do
Monitor hemoglobin per vadadustat labeling and adjust the vadadustat dose if the rise is too rapid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Glimepiride-pioglitazone with Vadadustat?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat is a substrate of OAT1/OAT3 transporters, and drugs inhibiting these may raise its exposure, which could cause an excessive hemoglobin rise. Pioglitazone is not an established clinically relevant inhibitor.
How serious is the interaction between Glimepiride-pioglitazone and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin per vadadustat labeling and adjust the vadadustat dose if the rise is too rapid.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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