Drug interactions
Glipizide + Gymnema
Severity: Moderate
Glipizide and Gymnema: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gymnema sylvestre has glucose-lowering activity and can add to the effect of sulfonylureas, raising the risk of hypoglycemia. Evidence is mostly from small studies and reports.
What this interaction means in plain words
Glipizide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering via enhanced insulin secretion and reduced intestinal glucose absorption.
What to do
Monitor blood glucose closely if gymnema is used and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Gymnema?
MediHelp rates the interaction as moderate. Glipizide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gymnema sylvestre has glucose-lowering activity and can add to the effect of sulfonylureas, raising the risk of hypoglycemia. Evidence is mostly from small studies and reports.
How serious is the interaction between Glipizide and Gymnema?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely if gymnema is used and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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