Drug interactions
Glipizide + Ibuprofen / famotidine
Severity: Minor
Glipizide and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination contains an NSAID and an H2 blocker. Ibuprofen may modestly potentiate the glucose-lowering effect of sulfonylureas, and famotidine's raising of gastric pH is not expected to meaningfully change glipizide absorption. Any hypoglycemic effect is usually small and manageable.
What this interaction means in plain words
Glipizide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible NSAID-related enhancement of sulfonylurea effect through protein binding displacement or reduced renal prostaglandins; effect of gastric pH is theoretical.
What to do
Monitor blood glucose when starting or stopping the combination and watch for symptoms of hypoglycemia. Reduce the glipizide dose if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Glipizide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The combination contains an NSAID and an H2 blocker. Ibuprofen may modestly potentiate the glucose-lowering effect of sulfonylureas, and famotidine's raising of gastric pH is not expected to meaningfully change glipizide absorption. Any hypoglycemic effect is usually small and manageable.
How serious is the interaction between Glipizide and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the combination and watch for symptoms of hypoglycemia. Reduce the glipizide dose if glucose falls.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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