Drug interactions
Glipizide + Indinavir
Severity: Moderate
Glipizide and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glipizide. Glycemic control can worsen after starting the protease inhibitor.
What this interaction means in plain words
Glipizide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitor-induced peripheral insulin resistance and impaired insulin secretion opposes sulfonylurea action.
What to do
Check blood glucose regularly after starting indinavir and titrate glipizide or add other antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Indinavir?
MediHelp rates the interaction as moderate. Glipizide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glipizide. Glycemic control can worsen after starting the protease inhibitor.
How serious is the interaction between Glipizide and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose regularly after starting indinavir and titrate glipizide or add other antidiabetic therapy as needed.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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