Drug interactions
Glipizide + Insulin aspart protamine / insulin aspart
Severity: Moderate
Glipizide and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glipizide and insulin have additive glucose-lowering effects, so combining them raises the risk of hypoglycemia. This combination is often used intentionally but needs dose adjustment.
What this interaction means in plain words
Glipizide and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: sulfonylurea-stimulated insulin secretion plus exogenous insulin.
What to do
Monitor blood glucose frequently when starting or changing either drug. Lower the glipizide or insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Glipizide and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glipizide and insulin have additive glucose-lowering effects, so combining them raises the risk of hypoglycemia. This combination is often used intentionally but needs dose adjustment.
How serious is the interaction between Glipizide and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting or changing either drug. Lower the glipizide or insulin dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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