Drug interactions
Glipizide + Lumacaftor / ivacaftor
Severity: Moderate
Glipizide and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor may induce CYP2C9 and reduce glipizide exposure. This can result in diminished glycemic control.
What this interaction means in plain words
Glipizide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP2C9, increasing glipizide clearance.
What to do
Monitor blood glucose after starting lumacaftor/ivacaftor and titrate glipizide as needed. Reassess the dose if the CFTR modulator is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Glipizide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor may induce CYP2C9 and reduce glipizide exposure. This can result in diminished glycemic control.
How serious is the interaction between Glipizide and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting lumacaftor/ivacaftor and titrate glipizide as needed. Reassess the dose if the CFTR modulator is stopped.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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