Drug interactions
Glipizide + Methyclothiazide
Severity: Moderate
Glipizide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide, a thiazide diuretic, can raise blood glucose and reduce the effect of glipizide. Worsening control may appear gradually after the diuretic is started.
What this interaction means in plain words
Glipizide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion plus increased insulin resistance oppose sulfonylurea action.
What to do
Monitor blood glucose and serum potassium after starting the thiazide. Increase the glipizide dose or add therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Methyclothiazide?
MediHelp rates the interaction as moderate. Glipizide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyclothiazide, a thiazide diuretic, can raise blood glucose and reduce the effect of glipizide. Worsening control may appear gradually after the diuretic is started.
How serious is the interaction between Glipizide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting the thiazide. Increase the glipizide dose or add therapy if control worsens.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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