Drug interactions
Glipizide + Methyltestosterone
Severity: Moderate
Glipizide and Methyltestosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens such as methyltestosterone may improve insulin sensitivity and lower blood glucose, potentially enhancing glipizide effect and raising hypoglycemia risk. The effect is usually modest.
What this interaction means in plain words
Glipizide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgens may increase insulin sensitivity and reduce blood glucose, adding to sulfonylurea effect.
What to do
Monitor blood glucose when methyltestosterone is started or stopped and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Methyltestosterone?
MediHelp rates the interaction as moderate. Glipizide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens such as methyltestosterone may improve insulin sensitivity and lower blood glucose, potentially enhancing glipizide effect and raising hypoglycemia risk. The effect is usually modest.
How serious is the interaction between Glipizide and Methyltestosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when methyltestosterone is started or stopped and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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