Drug interactions
Glipizide + Miconazole vaginal
Severity: Moderate
Glipizide and Miconazole vaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has limited but measurable systemic absorption and may inhibit CYP2C9, potentially raising glipizide levels. Hypoglycemia has been reported with miconazole and sulfonylureas.
What this interaction means in plain words
Glipizide and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9 metabolism of glipizide by absorbed miconazole.
What to do
Monitor blood glucose during and after vaginal miconazole courses and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Miconazole vaginal?
MediHelp rates the interaction as moderate. Glipizide and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vaginal miconazole has limited but measurable systemic absorption and may inhibit CYP2C9, potentially raising glipizide levels. Hypoglycemia has been reported with miconazole and sulfonylureas.
How serious is the interaction between Glipizide and Miconazole vaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after vaginal miconazole courses and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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