Drug interactions
Glipizide + Olanzapine
Severity: Moderate
Glipizide and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine commonly causes weight gain, insulin resistance and hyperglycaemia, which can reduce the effect of glipizide. Glycaemic control may deteriorate after olanzapine is started or its dose increased.
What this interaction means in plain words
Glipizide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: olanzapine-induced insulin resistance and impaired insulin secretion oppose sulfonylurea action.
What to do
Monitor fasting glucose and HbA1c regularly and adjust glipizide or add other agents as needed. Consider a lower metabolic-risk antipsychotic if control remains poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Olanzapine?
MediHelp rates the interaction as moderate. Glipizide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine commonly causes weight gain, insulin resistance and hyperglycaemia, which can reduce the effect of glipizide. Glycaemic control may deteriorate after olanzapine is started or its dose increased.
How serious is the interaction between Glipizide and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly and adjust glipizide or add other agents as needed. Consider a lower metabolic-risk antipsychotic if control remains poor.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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