Drug interactions
Glipizide + Oxandrolone
Severity: Moderate
Glipizide and Oxandrolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anabolic steroids such as oxandrolone can improve insulin sensitivity and lower blood glucose. When added to glipizide, they may increase the risk of hypoglycemia, especially in older or frail patients.
What this interaction means in plain words
Glipizide and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anabolic androgens enhance insulin sensitivity, producing an additive glucose-lowering effect with sulfonylureas.
What to do
Monitor blood glucose closely when oxandrolone is started, stopped or adjusted. Reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Oxandrolone?
MediHelp rates the interaction as moderate. Glipizide and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anabolic steroids such as oxandrolone can improve insulin sensitivity and lower blood glucose. When added to glipizide, they may increase the risk of hypoglycemia, especially in older or frail patients.
How serious is the interaction between Glipizide and Oxandrolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when oxandrolone is started, stopped or adjusted. Reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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