Drug interactions
Glipizide + Parecoxib
Severity: Minor
Glipizide and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is a COX-2 inhibitor. Its effect on glipizide is not well documented, and a significant pharmacokinetic interaction is unlikely, though NSAIDs can occasionally enhance hypoglycemia with sulfonylureas.
What this interaction means in plain words
Glipizide and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not established; possible NSAID-related enhancement of sulfonylurea effect.
What to do
Monitor blood glucose during parecoxib use, which is typically short-term, and adjust glipizide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Parecoxib?
MediHelp rates the interaction as minor. Glipizide and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is a COX-2 inhibitor. Its effect on glipizide is not well documented, and a significant pharmacokinetic interaction is unlikely, though NSAIDs can occasionally enhance hypoglycemia with sulfonylureas.
How serious is the interaction between Glipizide and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during parecoxib use, which is typically short-term, and adjust glipizide if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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