Drug interactions
Glipizide + Pindolol
Severity: Moderate
Glipizide and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations, and may prolong recovery from hypoglycemia. Nonselective agents like pindolol may also impair glycemic control, although pindolol's intrinsic sympathomimetic activity may reduce this.
What this interaction means in plain words
Glipizide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade masks hypoglycemia symptoms and impairs glycogenolysis-mediated glucose recovery.
What to do
Educate patients that sweating may be the main remaining warning sign and monitor blood glucose regularly. Consider a cardioselective beta blocker if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide and Pindolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Pindolol?
MediHelp rates the interaction as moderate. Glipizide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations, and may prolong recovery from hypoglycemia. Nonselective agents like pindolol may also impair glycemic control, although pindolol's intrinsic sympathomimetic activity may reduce this.
How serious is the interaction between Glipizide and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate patients that sweating may be the main remaining warning sign and monitor blood glucose regularly. Consider a cardioselective beta blocker if appropriate.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
