Drug interactions
Glipizide + Propranolol
Severity: Moderate
Glipizide and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can mask the adrenergic warning symptoms of hypoglycemia and delay recovery from it. Glucose control may also be somewhat impaired.
What this interaction means in plain words
Glipizide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade suppresses adrenergic counter-regulation and glycogenolysis, and reduces insulin secretion.
What to do
Monitor blood glucose more frequently and teach the patient that sweating may be the only warning sign. Prefer a cardioselective beta-blocker when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Propranolol?
MediHelp rates the interaction as moderate. Glipizide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can mask the adrenergic warning symptoms of hypoglycemia and delay recovery from it. Glucose control may also be somewhat impaired.
How serious is the interaction between Glipizide and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and teach the patient that sweating may be the only warning sign. Prefer a cardioselective beta-blocker when possible.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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