Drug interactions
Glipizide + Rifampin
Severity: Moderate
Glipizide and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces hepatic enzymes and can lower glipizide exposure, reducing glycemic control. Loss of effect may appear within days of starting rifampin, and hypoglycemia can occur after rifampin is stopped.
What this interaction means in plain words
Glipizide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2C9 and other hepatic enzymes by rifampin increases glipizide metabolism.
What to do
Monitor blood glucose when rifampin is started or stopped and increase the glipizide dose as needed. Reduce the dose again after rifampin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Rifampin?
MediHelp rates the interaction as moderate. Glipizide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces hepatic enzymes and can lower glipizide exposure, reducing glycemic control. Loss of effect may appear within days of starting rifampin, and hypoglycemia can occur after rifampin is stopped.
How serious is the interaction between Glipizide and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when rifampin is started or stopped and increase the glipizide dose as needed. Reduce the dose again after rifampin is discontinued.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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