Drug interactions
Glipizide + Salicylates
Severity: Moderate
Glipizide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can lower blood glucose and may add to the effect of glipizide. This increases the risk of hypoglycemia, especially at higher salicylate doses or with renal impairment.
What this interaction means in plain words
Glipizide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypoglycemic effect; possible displacement from protein binding and enhanced insulin secretion, though not fully established.
What to do
Monitor blood glucose when salicylates are started, stopped or changed in dose, and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Salicylates?
MediHelp rates the interaction as moderate. Glipizide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates can lower blood glucose and may add to the effect of glipizide. This increases the risk of hypoglycemia, especially at higher salicylate doses or with renal impairment.
How serious is the interaction between Glipizide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when salicylates are started, stopped or changed in dose, and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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