Drug interactions
Glipizide + Salsalate
Severity: Moderate
Glipizide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate, may potentiate the glucose-lowering effect of glipizide and raise the risk of hypoglycemia. Salsalate itself has been associated with lower glucose levels in diabetes.
What this interaction means in plain words
Glipizide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering effects of salicylates with sulfonylurea; mechanism not fully established.
What to do
Monitor blood glucose after starting salsalate and reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Salsalate?
MediHelp rates the interaction as moderate. Glipizide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate, may potentiate the glucose-lowering effect of glipizide and raise the risk of hypoglycemia. Salsalate itself has been associated with lower glucose levels in diabetes.
How serious is the interaction between Glipizide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting salsalate and reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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