Drug interactions
Glipizide + Selegiline transdermal
Severity: Moderate
Glipizide and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been associated with enhanced hypoglycemia in patients on antidiabetic drugs. Transdermal selegiline at antidepressant doses may carry a similar though less well documented risk.
What this interaction means in plain words
Glipizide and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition may enhance insulin secretion or sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting selegiline and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Selegiline transdermal?
MediHelp rates the interaction as moderate. Glipizide and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors have been associated with enhanced hypoglycemia in patients on antidiabetic drugs. Transdermal selegiline at antidepressant doses may carry a similar though less well documented risk.
How serious is the interaction between Glipizide and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting selegiline and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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