Drug interactions
Glipizide + Somatropin
Severity: Moderate
Glipizide and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of glipizide. Glycemic control can worsen after growth hormone is started or the dose is increased.
What this interaction means in plain words
Glipizide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and increases hepatic glucose output and lipolysis.
What to do
Monitor blood glucose and HbA1c when starting or adjusting somatropin. Increase the antidiabetic dose if needed, and reduce it again if somatropin is stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide and Somatropin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Somatropin?
MediHelp rates the interaction as moderate. Glipizide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of glipizide. Glycemic control can worsen after growth hormone is started or the dose is increased.
How serious is the interaction between Glipizide and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting somatropin. Increase the antidiabetic dose if needed, and reduce it again if somatropin is stopped to avoid hypoglycemia.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
